Preheat your oven to 375°F (190°C) and line a baking sheet with parchment paper.

Lay one large flour tortilla flat and layer slices of roast beef and shredded cheese in the center.

Roll the tortilla tightly, folding in the sides to secure the filling, and place seam-side down on the baking sheet.

Brush the tops and sides with melted butter, then sprinkle with garlic powder, onion powder, and dried parsley.

Bake in the preheated oven for 12 to 15 minutes until golden brown and cheese is melted.

While baking, prepare the au jus by simmering beef broth, Worcestershire sauce, soy sauce, garlic powder, onion powder, salt, and pepper in a saucepan for 5–7 minutes.

Allow roll ups to cool slightly, then slice into bite-sized pieces and serve with the au jus.